Skip to content

Explore a key suspect behind the signs and symptoms of atopic dermatitis

Look closer at how Th2 cytokines, including IL-13, drive skin inflammation1-4

Graphic designed by ADKeysuspect.com.au of female suffering from atopic dermatitis of the face and neck

Uncover the burden
of disease

The chronic, persistent nature of atopic dermatitis (AD) means it’s always there, even when patients may appear asymptomatic. The cycle of chronic itch and inflammation can have a significant impact on patients.1,4

UNCOVER MORE

Explore the role of Th2 cytokines that drive atopic dermatitis

Th2 cytokines are the key drivers of the inflammatory cascade associated with atopic dermatitis. How these manifest can differ across non-lesional, acute lesional, and chronic lesional skin.5

EXPLORE MORE

Discover the role
of IL-13 in AD

IL-13 plays a key role in the inflammation underlying AD signs and symptoms. In AD skin, overexpression of IL-13 leads to a variety of pathophysiologic issues, including disruption of the skin barrier and amplified inflammation.6-12

DISCOVER MORE

Find out first

Register to receive exclusive news, updates and data.

References

  1. Suárez-Fariñas M, Tintle S, Shemer A, et al. Non-lesional atopic dermatitis (AD) skin is characterized by broad terminal differentiation defects and variable immune abnormalities. J Allergy Clin Immunol. 2011;127(4):954-964.e1-4.
  2. Tazawa T, Sugiura H, Sugiura Y, Uehara M. Relative importance of IL-4 and IL-13 in lesional skin of atopic dermatitis. Arch Dermatol Res. 2004;295(11):459-464.
  3. Gittler JK, Shemer A, Suárez-Fariñas M, et al. Progressive activation of Th2/Th22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. J Allergy Clin Immunol. 2012;130(6):1344-1354.
  4. Silverberg JI, Kantor R. The role of interleukins 4 and/or 13 in the pathophysiology and treatment of atopic dermatitis. Dermatol Clin. 2017;35(3):327-334.
  5. Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD. Atopic dermatitis. Nat Rev Dis Primers. 2018;4(1):1-20.
  6. Kim BE, Leung DY, Boguniewicz M, Howell MD. Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. Clin Immunol. 2008;126(3):332-337.
  7. Berdyshev E, Golvea E, Bronova I, et al. Lipid abnormalities in atopic skin are driven by type 2 cytokines. JCI Insight. 2018;3(4):e98006.
  8. Nomura I, Goleva E, Howell MD, et al. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes.
    J Immunol. 2003;171(6):3262-3269.
  9. Purwar R, Werfel T, Wittmann M. IL-13-stimulated human keratinocytes preferentially attract CD4+CCR4+ T cells: possible role in atopic dermatitis. J Invest Dermatol. 2006;126(5):1043-1051.
  10. Oetjen LK, Mack MR, Feng J, et al. Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch. Cell. 2017;171(1):217-28.e13.
  11. Moriya C, Jinnin M, Yamane K, et al. Expression of matrix metalloproteinase-13 is controlled by IL-13 via PI3K/Akt3 and PKC-δ in normal human dermal fibroblasts.
    J Invest Dermatol. 2011;131(3):655-661.
  12. Mack MR, Kim BS. The itch-scratch cycle: a neuroimmune perspective. Trends Immunol. 2018;39(12):980-991.