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The chronic, persistent nature of atopic dermatitis means it’s always there, even when patients may appear asymptomatic.1

Atopic Dermatitis Burden: Debilitating and more severe
when uncontrolled

  • Characterised by intense itching and recurrent lesions, atopic dermatitis inflicts a substantial physical and mental burden on patients.2
  • Patients with moderate to severe atopic dermatitis report potentially debilitating signs and symptoms  such as excessive itch, dryness, scaling, and open sores – all of which can lead lead to sleep disturbance, pain, and impaired social functioning.3

Patients with inadequately controlled atopic dermatitis suffer greater physician-rated disease severity and physician-rated burden than those with controlled atopic dermatitis4

Correlation of atopic dermatitis disease severity with inadequate disease control



Disease burden in controlled vs inadequately controlled atopic dermatitis patients

graph created by comparing inadequately controlled vs controlled atopic dermatitis. The graph highlights the impact of inadequately controlled AD on depression, stress, itch, and sleep disturbance. Adapted from Wei W et al.3 


A chronic and persistent condition, atopic dermatitis can manifest differently in each patient.5

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  1. Suárez-Fariñas M, Tintle SJ, Shemer A, et al. Non-lesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities. J Allergy Clin Immunol. 2011;127(4):954-964.e1-4.
  2. Weidinger S, Novak N. Atopic dermatitis. Lancet. 2016;387(10023):1109-1122.
  3. Silverberg JI, Kantor R. The role of interleukins 4 and/or 13 in the pathophysiology and treatment of atopic dermatitis. Dermatol Clin. 2017;35(3):327-334.
  4. Wei W, Anderson P, Gadkari A, et al. Extent and consequences of inadequate disease control among adults with a history of moderate to severe atopic dermatitis. J Dermatol. 2018;45(2):150-157.
  5. Silverberg JI, Gelfand JM, Margolis DJ, et al. Patient burden and quality of life in atopic dermatitis in US adults: a population-based cross-sectional study. Ann Allergy Asthma Immunol. 2018;121(3):340-347.