Expression levels of IL-13 in lesional skin correlates with disease severity. 1,2

IL-13 mRNA Expression in Lesional Skin Correlates With SCORAD

mRNA expression levels of IL-13 in lesional skin were correlated with disease severity, as measured by SCORing Atopic Dermatitis (SCORAD)1

Chart created by ADKeySuspect.com.au showing IL-13 mRNA expression in lesional skin and correlation with SCORAD

IL-13 Protein Levels in Lesional Skin Correlate With Objective SCORAD*

Based on IL-13 protein levels in skin-derived interstitial fluid (ISF), a strong correlation with disease severity as measured by objective SCORAD was established

 

Overall, the growing body of evidence supports that IL-13 is a primary cytokine involved in driving skin inflammation in AD.1-3

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References

  1. Tsoi LC, Rodriguez E, Degenhardt F, et al. Atopic dermatitis is an IL-13-dominant disease with greater molecular heterogeneity compared to psoriasis. J Invest Dermatol. 2019;139(7):1480-1489.
  2. Szegedi K, Lutter R, Res PC, et al. Cytokine profiles in interstitial fluid from chronic atopic dermatitis skin. J Eur Acad Dermatol Venereol. 2015;29(11):2136-2144.
  3. Koppes SA, Brans R, Ljubojevic Hadzavdic S, Frings-Dresen MH, Rustemeyer T, Kezic S. Stratum corneum tape stripping: monitoring of inflammatory mediators in atopic dermatitis patients using topical therapy. Int Arch Allergy Immunol. 2016;170(3):187-193.