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Atopic dermatitis is an unpredictable, complex disease that can manifest differently in each patient, and there’s a large unmet need for long-term disease control.1,2

Atopic dermatitis is an unpredictable, complex
disease with varying1:

  • Degrees of severity
  • Skin involvement
  • Frequency of flares

Despite advancements, more management options are needed2,7

Understanding the difficulties that patients face is just one part to tackling this debilitating disease. Atopic dermatitis has a complex pathophysiology that drives the visible signs, symptoms, and underlying inflammation. 8-10

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References

  1. Silverberg JI, Gelfand JM, Margolis DJ, et al. Patient burden and quality of life in atopic dermatitis in US adults: a population-based cross-sectional study. Ann Allergy Asthma Immunol. 2018;121(3):340-347.
  2. Renert-Yuval Y, Guttman-Yassky E. New treatments for atopic dermatitis targeting beyond IL-4/IL-13 cytokines. Ann Allergy Asthma Immunol. 2020;124:28-35.
  3. Abuabara K, Margolis DJ, Langan SM. The long-term course of atopic dermatitis. Dermatol Clin. 2017;35(3):291-297.
  4. Tsai TF, Rajagopalan M, Chu CY, et al. Burden of atopic dermatitis in Asia. J Dermatol. 2019;46(10):825-834.
  5. Reed B, Blaiss MS. The burden of atopic dermatitis. Allergy Asthma Proc. 2018;39(6):406-410.
  6. Zuberbier T, Orlow SJ, Paller AS, et al. Patient perspectives on the management of atopic dermatitis. J Allergy Clin Immunol. 2006;118(1):226-232.
  7. Weidinger S, Novak N. Lancet. 2016;387:1109-1122.
  8. Jakasa I, Verberk MM, Esposito M, Bos JD, Kezic S. Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients. J Invest Dermatol. 2007;127(1):129-134.
  9. May RD, Fung M. Strategies targeting the IL-4/IL-13 axes in disease. Cytokine. 2015;75(1):89-116.
  10. Williams MR, Gallo RL. The role of the skin microbiome in atopic dermatitis. Curr Allergy Asthma Rep. 2015;15(65):1-10.